![]() ![]() Many genetic, molecular, and neuroanatomic/neurochemical alterations have been described in individuals with ADHD, that share some similarity and overlap with the neuroanatomic/neurochemical alterations implicated in the development of late-life dementias such as AD, dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD). It is currently unclear if other developmental disorders such as ADHD also predispose to the development of late-life cognitive decline. The evidence linking the molecular pathogenesis of Down syndrome to the precocious development of AD is irrefutable. Persons with Down syndrome universally develop the pathological changes of Alzheimer’s disease (AD) by age 40. The strongest evidence for developmental disorders predisposing affected persons to the development of late-life cognitive decline involves Down syndrome, in which affected individuals inherit a triplication of the chromosome 21 region encoding for the amyloid precursor protein (APP). Most developmental disabilities are related to intrinsic molecular, neuroanatomic, and neurochemical disturbances, that persist throughout life, potentially predisposing to late-life cognitive decline. ADHD is considered the most prevalent cause of childhood learning disabilities. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |